Medicine

Accelerating ASO therapies from growth to execution

.Competing passions.R.S., M.S., H.G. as well as A.A.R. are actually organizers of the 1M1M initiative. H.G. as well as A.A.R. are board of directors members as well as R.S., M.S. as well as A.A.R. are members of the clinical consultatory committee of N1C. A.A.R. reveals work through LUMC, which has patents on exon-skipping modern technology, several of which has been actually certified to BioMarin and ultimately sublicensed to Sarepta. As co-inventor of a few of these licenses, A.A.R. was entitled to an allotment of royalties. A.A.R. even further makes known acting as ad hoc consultant for PTC Therapies, Sarepta Rehabs, Regenxbio, Dyne Rehabs, Lilly, BioMarin Pharmaceuticals Inc., Eisai, Entrada, Takeda, Splicesense, Galapagos, Sapreme, Italfarmaco and also Astra Zeneca. Previously 5 years, A.A.R. also performed ad hoc speaking to for Alpha Anomeric. A.A.R. additionally mentions subscription of the medical boards of advisers of Eisai, Hybridize Therapies, Silence Rehabs, Sarepta Therapies, Sapreme and also Mitorx. Previously 5 years, A.A.R. was actually additionally a scientific advisory board member for ProQR. Wage for A.A.R. u00e2 s consulting and suggesting tasks is paid out to LUMC. In the past 5 years, LUMC additionally acquired audio speaker honoraria from PTC Therapies, Alnylam Netherlands, Italfarmaco and also Pfizer and also funding for contract research coming from Sapreme, Eisai, Galapagos, Synaffix as well as Alpha Anomeric. Project funding is actually received coming from Sarepta Therapeutics and also Entrada using unconstrained grants. H.G. possesses nothing to divulge in connection with the topics dealt with in this manuscript. In the past 5 years, he has actually also obtained working as a consultant honoraria from UCB. M.S. obtained consultancy gratuity coming from Ionis, UCB, Prevail, Orphazyme, Biogen, Servier, Reata, GenOrph, AviadoBio, Biohaven, Zevra, Lilly and also Solaxa in the past 5 years, all unassociated to the here and now composition. R.S. possesses absolutely nothing to disclose in relation to the subject matters dealt with within this manuscript. She has actually gotten speaker and/or working as a consultant honoraria or sponsoring contributions coming from Abbvie, Bial, STADA and also Everpharma before 5 years.