.Nature Medicine, Published online: 18 September 2024 doi:10.1038/ s41591-024-03300-3Genomic and epidemiologic evaluations disclosed that an unfamiliar reassortant popular family tree of the Oropouche infection, which has been flowing in the western side Amazon region of South america for concerning a years, is linked with the latest individual break outs between 2022 as well as 2024.